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KMID : 0988920200180040379
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Intestinal Research
2020 Volume.18 No. 4 p.379 ~ p.401
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Fibrostenotic strictures in Crohn’s disease
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Yoo Jun-Hwan
Holubar Stefan
Rieder Florian
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Abstract
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The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies followed by anti-integrins and anti-interleukins has drastically changed the treatment paradigm of Crohn’s disease (CD) by improving clinical symptoms and mucosal healing. However, up to 70% of CD patients still eventually undergo surgery mainly due to fibrostenotic strictures. There are no specific anti-fibrotic drugs yet. This review comprehensively addresses the mechanism, prediction, diagnosis and treatment of the fibrostenotic strictures in CD. We also introduce promising anti-fibrotic agents which may be available in the near future and summarize challenges in developing novel therapies to treat fibrostenotic strictures in CD.
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KEYWORD
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Crohn disease, Stricture, Fibrostenosis, Intestinal fibrosis, Endoscopic balloon dilatation
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